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Medication Errors Seen in Half of All Operations in Study

By Alan Mozes
HealthDay Reporter

SUNDAY, Oct. 25, 2015 (HealthDay News) — In a new study on how often medication errors occur during surgery, researchers report that mistakes were made during almost half of the operations they analyzed.

The mistakes included drug labeling errors, incorrect dosing, drug documentation mistakes, and/or failing to properly treat changes in a patient’s vital signs during surgery.

Overall, a medication error or adverse drug event was documented in 124 of 277 surgeries. Of the 3,675 medication administrations (most patients receive more than one drug during surgery), 193 medication errors and adverse drug events were recorded, the Harvard researchers said. And almost 80 percent of those events were determined to have been preventable.

The findings stem from the in-house efforts of Boston-based Massachusetts General Hospital to quantify and address drug-error risk during surgery.

“This is the first large-scale look at medication errors in the time immediately before, during and directly after surgery,” said study author Dr. Karen Nanji, an assistant professor of anesthesia at Harvard Medical School in Boston. “But in my opinion, while there is much room for improvement, our results are not surprising,” she added.

“In fact, it’s very likely that this issue is even more problematic given that Mass General is a national leader in patient safety, and has gone out of its way to study this issue in order to improve outcomes,” she suggested.

Nanji, who is also with department of anesthesia, critical care and pain medicine at Massachusetts General, reported her team’s findings online Oct. 25 in the journal Anesthesiology.

The study authors noted that rigorous safety checks commonly in place across many hospital settings are often loosened or bypassed in the surgical environment, when fast-moving events and changing circumstances can require quick decisions and immediate action.

With that in mind, the investigators focused on operations performed at Massachusetts General over seven months in 2013 and 2014.

All drugs and drug errors were recorded (or gleaned from medical charts) covering the time a patient entered a pre-operative area until they were out of surgery and in either a recovery room or an intensive care unit.

The result: more than 5 percent of the time, drugs were given in error or negative drug events were observed.

Two-thirds of the drug errors were categorized as “serious,” while 2 percent were considered life-threatening (though none of the patients died as a result). The remaining errors were considered “significant.”

“Hospitals across the country are constantly looking for ways to improve patient care,” said Dr. John Combes, chief medical officer of the American Hospital Association in Washington, D.C.

“This study provides important insights and highlights areas of focus for further action and study. By learning the root cause of such errors, hospitals and health systems can work to provide the best patient experience for each episode of care,” Combes suggested.

Meanwhile, Dr. David Katz, director of the Yale University Prevention Research Center in New Haven, Conn., said that “awareness of problems is where all solutions begin.”

He pointed out that “these numbers are disturbing, but not surprising. Those of us who have worked in hospitals have seen innumerable instances when such errors did occur, or could have.”

Katz explained that “medical care is intense, and often rather complex. Many parts are in motion, the stakes are high and there is often time pressure. While in some ways it is surprising that highly trained professionals working in teams would make mistakes, we might compare these teams to the other teams we know well: professional sports teams. They, too, are highly trained, exclusive teams — and yet [they] make errors routinely,” he noted.

“Of course, in medicine, it’s not about winning and losing games; it is about life and death,” Katz said. “In such context, no error is acceptable. And yet, as the saying goes, to err is human. So errors will occur if human behavior is the only safeguard against it,” he said.

“What all this means is that human behavior cannot be the only safeguard against error,” Katz added. “Rather, we need a multi-layered defense, involving careful humans backing one another up, and automatic systems backing up the humans.”

More information

There’s more on anesthesia safety at The Association of Anaesthetists.





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Nitrous Oxide OK During Surgery for People With Heart Disease

SUNDAY, Oct. 25, 2015 (HealthDay News) — Nitrous oxide, commonly known as “laughing gas,” is a safe anesthetic for surgery patients who have or are at risk of heart disease, a new study finds.

The findings are “welcome news because nitrous oxide is widely used around the world as part of the mixture of agents for general anesthesia,” lead author Dr. Kate Leslie, a professor at Royal Melbourne Hospital in Australia, said in an American Society of Anesthesiologists news release.

“Nitrous oxide is inexpensive, simple to administer and helps with pain as well as anesthesia,” she added.

The research included nearly 6,000 patients. All had surgery that didn’t involve the heart. The study volunteers received either general anesthesia with nitrous oxide or general anesthesia with nitrogen.

A year after surgery, there was no difference in rates of heart attack, stroke, disability or death between the two groups, the study found.

The study is to be presented Sunday at the annual meeting of the American Society of Anesthesiologists, in San Diego. The study will also be published online Oct. 25 in the journal Anesthesiology.

“This helps alleviate concerns raised in recent years about the effect of nitrous oxide on the heart and vascular system,” Leslie said.

More information

The U.S. National Library of Medicine has more about anesthesia.





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Light Meal During Labor May Be Safe for Most Women: Study

SATURDAY, Oct. 24, 2015 (HealthDay News) — Labor and delivery is often a grueling ordeal for many women, and current guidelines rule out eating.

But new Canadian research suggests that a light meal during labor could be a good idea for most healthy women.

“Our findings suggest a change in practice makes sense,” study co-author Christopher Harty, a medical student at Memorial University, St. John’s, Newfoundland, said in an news release from the American Society of Anesthesiologists.

He was slated to present the findings Saturday at the society’s annual meeting in San Diego.

Traditionally, women have been told to avoid eating or drinking during labor due to concerns they might inhale food or liquid into their lungs — a condition known as aspiration. Aspiration, in turn, can sometimes lead to pneumonia, the researchers said

But they noted that medical advances have now made this problem highly unlikely in modern settings. According to the researchers, aspiration during labor is extremely rare: In the United States, there was only one case of aspiration during labor and delivery between 2005 and 2013.

The low risk of aspiration is likely due to advances in anesthesia care, such as increased use of epidurals and spinal blocks instead of delivering anesthesia through a mask over the nose and mouth, the researchers said.

In the new study, Harty’s team revisited the issue. They reviewed 385 studies published since 1990 and concluded that avoiding food and liquids during labor may be unnecessary for many women.

In fact, having a light meal may be beneficial because the energy and caloric demands of labor are so high for women — similar to running a marathon, according to the researchers.

Instead of setting a “no eating” rule, “anesthesiologists and obstetricians should work together to assess each patient individually,” Harty said. “Those they determine are at low risk for aspiration can likely eat a light meal during labor. This gives expectant mothers more choices in their birthing experience and prevents them from being calorie-deficient, helping to provide energy during labor.”

Two experts agreed with the notion, but added that identifying patients at “low risk” for aspiration is key.

“A light meal during labor may be beneficial for most low-risk pregnant women, especially those who wish to have early, continuous regional [pain control],” said Dr. Anthony Vintzileos, chair of obstetrics and gynecology at Winthrop-University Hospital in Mineola, N.Y.

But he pointed out that aspiration can be an issue if an emergency Cesarean section is required due to fetal distress. In those cases, general anesthesia may be used, and “a recent maternal meal may place the woman at risk for aspiration,” Vintzileos explained.

Therefore, “the anesthesiologist and obstetricians should exercise good judgment to assess each patient individually for having a light or liquid meal during labor,” he said.

Dr. Francine Hippolyte is an obstetrician/gynecologist at Long Island Jewish Medical Center in New Hyde Park, N.Y. She agreed with the study authors that “low-risk moms benefit significantly when allowed to eat in labor — It’s an important consideration, given the unpredictable duration of labor and delivery in addition to all the energy and effort that is needed during and after the labor experience.”

“Once a patient is correctly identified as low risk, she should at minimum be allowed to have a clear liquid diet, especially given the advances in anesthesia and the results from recent studies,” Hippolyte said.

Experts note that findings presented at medical meetings should be considered preliminary until published in a peer-reviewed journal.

More information

The U.S. Office on Women’s Health has more on labor and birth.





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Unexpected Severe Allergic Reactions Strike Many Schools

SATURDAY, Oct. 24, 2015 (HealthDay News) — More than one in 10 U.S. schools reported at least one student who suffered a severe allergic reaction during the 2013-14 school year, new research shows.

And 22 percent of those students had no previously known allergies, the researchers added. Epinephrine is typically used to treat severe allergic reactions (anaphylaxis).

“There’s always a first time for a reaction — it can be at home, it can be in school, it can be in a restaurant, it can be on the soccer field,” said study author Dr. Martha White, research director of the Institute for Asthma & Allergy in Wheaton, Md.

“But the bottom line is that many students experiencing anaphylaxis in school had no prior known allergies and would not have had medication there or at home,” she said in a news release from the American Academy of Pediatrics (AAP).

The study included more than 6,000 schools participating in the Epipen4Schools program, which provides free epinephrine auto-injectors to more than 59,000 public and private schools across the country.

Of the 919 severe allergic reactions reported by the schools in the study, 75 percent of patients were treated with epinephrine auto-injectors, while 18 percent were treated with antihistamines. The most common triggers of the allergic reactions were food (62 percent) and insect stings (10 percent). Triggers could not be pinpointed in 20 percent of the cases.

The findings suggest that a significant number of children suffer their first severe allergic reaction while in school, and there is a need for greater access to epinephrine auto-injectors in schools, White said.

The study, to be presented Saturday at AAP’s annual meeting in Washington, D.C., was funded by Mylan Specialty, which markets epinephrine auto-injectors. Findings presented at meetings are generally considered preliminary until published in a peer-reviewed journal.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about anaphylaxis.





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Limiting Tackling Limits Concussions: Study

SATURDAY, Oct. 24, 2015 (HealthDay News) — Limiting tackling during high school football practices can significantly reduces players’ concussion rates, a new study indicates.

In 2014, new rules about tackling during football practice were introduced for Wisconsin high schools.

Full contact was banned during the first week of practice, and limited to 75 minutes during the second week. After that, full contact during practice was capped at 60 minutes for every week. Full contact means that tackles are made at a competitive level and players are taken to the ground, the researchers explained.

The number of concussions that occurred during practice was more than twice as high during the two seasons before the new rules began, the study said.

The findings were to be presented Saturday at the American Academy of Pediatrics annual meeting in Washington, D.C. Research presented at meetings are generally viewed as preliminary until they’ve been published in a peer-reviewed journal.

“This study confirms what athletic trainers who work with high school football programs have long believed regarding the association of full contact drills or practices and the likelihood a player will sustain a concussion,” study author Timothy McGuine, from the University of Wisconsin-Madison, said in an academy news release.

McGuine said the possibility of other football injuries, such as sprains, fractures and dislocations, should also drop due to the new practice rules.

“Educating high school coaches to limit the amount of full contact would be an effective and economical way to help protect students from head injuries,” McGuine concluded.

More information

The American Academy of Family Physicians has more about concussion.





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Kids in Foster Care Have Tripled Rates of ADHD, Study Finds

FRIDAY, Oct. 23, 2015 (HealthDay News) — Children in foster care are three times more likely to have been diagnosed with attention-deficit/hyperactivity disorder (ADHD) than those in the general population, a new study reveals.

For the study, researchers at the U.S. Centers for Disease Control and Prevention looked at 2011 Medicaid data from across the United States.

The investigators found that more than one in four children aged 2 to 17 in foster care had an ADHD diagnosis, compared with just one in 14 of those not in foster care.

About half of the children with ADHD in foster care also had some other psychological disorder, such as depression, anxiety or oppositional defiant disorder. In contrast, only about one-third of kids with ADHD who were not in foster care had another condition, the CDC team said.

Why the disparities? One expert not connected to the study said the reasons aren’t fully clear.

“It is likely a combination of many factors — some relating to the child and others relating to the mother,” said Dr. Andrew Adesman, chief of developmental and behavioral pediatrics at Cohen Children’s Medical Center of New York, in New Hyde Park, N.Y.

For example, “some children are placed in foster care because of prior neglect or abuse by a parent — and we know that children who are hyperactive are at increased risk for abuse because of the parenting challenges that they sometimes pose,” he said.

“Children in foster care are also often the product of an unplanned or unwanted pregnancy,” Adesman added. “Unplanned pregnancies are more common in mothers who themselves have ADHD, and women with an unwanted pregnancy may have also put their pregnancy at risk for later ADHD through drug and alcohol use, or failure to get prenatal care.”

The new report did have some good news, however: All children with ADHD, regardless of their home situation, were equally likely to be treated with ADHD medication, the study found. In addition, those in foster care were actually more likely to receive psychological care than those not in foster care, with a treatment rate of 75 percent.

The study is to be presented on Monday at the American Academy of Pediatrics (AAP) national meeting in Washington, D.C.

There is a significant need for medical and behavioral services for foster children with ADHD, according to lead author Melissa Danielson, a statistician at the CDC’s National Center on Birth Defects and Developmental Disabilities.

And the finding that many children with ADHD in foster care receive psychological services is promising, she added.

“As we work to improve the quality of care for children with ADHD, it will be important to consider the needs of special populations, including those in foster care,” Danielson said in an AAP news release. “Working together, primary care and specialty clinicians can best support the health and long-term well-being of children with ADHD.”

Experts note that findings presented at medical meetings are typically considered preliminary until published in a peer-reviewed journal.

More information

The U.S. National Institute of Mental Health has more about attention-deficit/hyperactivity disorder.





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5 Important Relationship Lessons We Learned From Gilmore Girls

(Photo: Giphy)

 

October 19, 2015: The day it was announced Gilmore Girls is getting a four-episode revival on Netflix, and millennial women (and their moms) across the internet started dancing like Sookie.

Though the rumored quartet of 90-minute episodes isn’t officially confirmed just yet, it’s basically a done deal, and cast negotiations have already started to get Lauren Graham and Alexis Bledel back on board. And while Lorelai and Rory’s unique mother-daughter bond is one of our favorite relationships from the show’s seven-season run, the series was filled with every kind of relationship—friends, boyfriends, parents—and taught us so much about what it means to be in one.

 

(Photo: Giphy)

 

Here are 5 things Gilmore Girls taught us:

RELATED: 20 Weird Facts About Sex and Love

Love come with a lot of happiness, and a lot of turmoil

 

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(Photo: Giphy)

Rory’s first real relationship was a major adjustmentfor her, and for Lorelai. Young viewers of the show watched and learned as Rory navigated the waters of having her first boyfriend— who could forget the first awkward kiss (plus a little light shoplifting), the first homecoming dance, the first breakup?

 

(Photo: thelorelais.tumblr.com)

 

It’s okay to get hurt because you learn from it

 

(Photo: Giphy)

At first, Dean seemed like the perfect boyfriendhe loved Rory fiercely, got along great with LorelaiI mean, he built Rory a freakin’ car! But even those on #TeamDean can’t deny the ridiculous chemistry when Jess came along. Which meant a torturous breakup with Dean, even more conflict between Rory and Lorelai and added heartbreak, especially when Jess left for California. But in the end, Rory and Jess learned so much from each other, and they clearly wouldn’t be where they are now without that relationship.

(Photo: Giphy)

 

Find someone who understands you

 

(Photo: Giphy)

Everyone knows that Luke and Lorelai were the only possible endgame (except maybe for Lorelai by herself, because girlpower, amirite?). Theirs was an epic, will-they-won’t-they relationship, with Luke mostly waiting on the sidelines as Lorelai dated other guys who were clearly wrong for her (ahem, Digger Stiles). But Luke+Lorelai perfectly complimented each other, with his surliness and her sarcasm. Even if you have to date some frogs, you’ll eventually find your prince.

(Photo: Giphy)

RELATED: How Love Changes Your Body Chemistry

You don’t need a man! All you need is a good friend

 

(Photos: Buzzfeed and tookieclothespins.tumblr.com)

Paris and Rory started as fierce enemies (mostly on Paris’ end), but they grew out of petty fights over guys, and became an awesome, feminist friendship (and there’s even fandoms out there who eschew #TeamDean or #TeamJess for #TeamParis…).

(Photo: unwrittenletterss.tumblr.com)

 

Your relationship with your mom may not be perfect, but that’s okay

 

(Photo: Giphy)

Emily and Lorelai were, of course, essentially estranged at the start of the show. Still, Emily always worked to give Lorelai the very best, and even if the way she did it was misguided, her heart was there. Meanwhile, Lorelai, who had spent so long trying to build up an independent life of her own, had to learn when to accept help from her mom. Both showed us that mother-daughter relationships can be tricky and complex, but where would you really be without your mom?

RELATED: 20 Ways to Fall In Love All Over Again




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Drew Barrymore on Postpartum Depression: ‘I Really Got Under the Cloud’

Photo: Getty Images

Photo: Getty Images

We already love Drew Barrymore for just how relatable and down-to-earth she can be—especially for someone who’s worked in Hollywood since childhood—and now she’s getting even realer. Barrymore opened up to People about how she went through a phase of postpartum depression after the birth of her second daughter, Frankie, 18 months.

“I didn’t have postpartum the first time so I didn’t understand it because I was like, ‘I feel great!’ The second time, I was like, ‘Oh, whoa, I see what people talk about now. I understand,’ ” she said. “It’s a different type of overwhelming with the second. I really got under the cloud.”

Barrymore is one of the many celebrities who have spoken out recently about their struggles with postpartum depression.

RELATED: 11 Celebrities Who Battled Postpartum Depression

Thankfully, Barrymore says the postpartum depression was “short-lived, probably six months,” and it taught her to enjoy every moment with Frankie and her first daughter, Olive, 3, especially when managing issues with work.

“It’s really important. I was in the kids’ class with Frankie and Olive this morning and I started fretting about some piece of work news that was just stressful,” she said. “You know, in like the Broadway Babies class and it’s the one-hit wonders day, and they’re singing I don’t even know what song, and we’re all doing our lollipop drums and I just thought, ‘Save it until after class.’ One thing at a time.”

Another thing she won’t being stressing about: her weight. “Having a hot body is just not my thing. I care a little, I don’t care a lot,” she said.

RELATED: Drew Barrymore Doesn’t Care About Having a Bikini Body: ‘I Am Who I Am’

 




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Introducing Julia: Sesame Street’s New Character With Autism

 

For years, Sesame Street has educated children not only about academics, but also important life lessons. This week was no exception when they unveiled their newest character: Julia.

In a statement to ABC News, the Sesame Street Workshop described Julia as a “preschool girl with autism who does things a little differently when playing with her friends, the lovable Elmo, Abby Cadabby, and Grover.”

Julia joins her pals in a series of online storybooks, videos and interactive games all part of Sesame Street’s campaign called Sesame Street and Autism: See Amazing in All Children, an initiative to fight the stigma surrounding the disorder.

Children with autism are five times more likely to get bullied,” Jeanette Betancourt, Ed.D., senior vice president of social impact for Sesame Street, explained to People. “And with one in 68 children having autism, that’s a lot of bullying. Our goal is to bring forth what all children share in common, not their differences.”

RELATED: How My Son’s Autism Changed Everything

The U.S. Centers for Disease Control and Prevention (CDC) reports diagnoses have been on a steady rise over the past decade, which may be due to better reporting. Yet, according to the Sesame Street website: “While the diagnosis is common, public understanding of autism is not.”

That’s where characters like Julia have a lot to teach both children and parents.

For example, in one of the online story books, Elmo says to his friend Abby: “Elmo’s daddy told Elmo that Julia has autism. So she does things a little differently.” While maintaining a tone of acceptance and compassion, Elmo explains that at times he talks to Julia using fewer words and says the same thing a few times.

“This is what makes our project so unique,” Betancourt told People. “When we explain from a child’s point of view that there are certain behaviors, such as slapping their hands or making noises, to express excitement or unhappiness, it helps younger children to understand how to interact with their autistic peers. It makes children more comfortable and therefore more inclusive.”

RELATED: How ADHD is Different in Boys and Girls

But Sesame Street’s initiative isn’t limited to awareness-raising stories. They also offer a free app with routine cards to make day-to-day life easier for families with autistic children along with resources for care providers and helpful organizations they can turn to. Plus, the educational efforts of the campaign may even help parents realize their child is living with autism, and consequently take steps to help improve his or her quality of life.

To top it off, the campaign created a video called “The Amazing Song” which features Elmo, Abby Cadabby, and a group of autistic children. This heartwarming campaign gives hope that future generations of children will respect rather than bring down each other for their differences.

“We are trying to spread the story about the theory behind this whole thing: love and acceptance,” Betancourt explained. “Everyone is touched by autism, and by creating Julia, Sesame is bringing children together.”

RELATED: How My Son’s Autism Changed Everything




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Drug Company Announces They’ll Offer a $1 Alternative to That $750 Pill

Photo: Getty Images

Photo: Getty Images

Back in September, news broke that a CEO by the name of Martin Shrkeli had raised the price of a 62-year-old generic drug, Daraprim, from $13.50 to a whopping $750 a capsule overnight, leading to widespread shock and outrage. (The drug is often prescribed to AIDS and cancer patients.) Well now, it seems this devilish tale has a hero: A San Diego-based biomedical company announced yesterday that they will offer a comparable drug for around $1 per pill.

The company, Imprimis Pharmaceuticals, plans to supply pills containing Daraprim’s active ingredients, pyrimethamine and leucovorin, in 100-capsule bottles on their website for as low as $99.

They are able to do this because Imprimis is a drug compounder, meaning the company makes specific formulations of drugs tailored to individual needs of patients. The company’s CEO, Mark Baum, told The San Diego Union-Tribune that this formulation isn’t FDA-approved, only the ingredients are, so it can only be sold through a doctor’s prescription and made for a specific individual. This work-around is what allows the company to keep the costs low.

Imprimis also announced they won’t limit their efforts to an affordable Daraprim, they also plan to compete with other manufacturers who have significantly spiked the cost of their drug prices, Baum told The Associated Press.

RELATED: 6 Insane Examples of Prescription Drug Price Increases

“In response to this recent case and others that we will soon identify, Imprimis is forming a new program called Imprimis Cares which is aligned to our corporate mission of making novel and customizable medicines available to physicians and patients today at accessible prices,” Baum said in a press release about the announcement.

“We are looking at all of these cases where the sole-source generic companies are jacking the price way up,” Baum explained to the AP. He predicts there will be a surge of these compounded drugs in the near future as a way to rein in drug prices.

After all, Turing Pharmaceuticals isn’t the only company to drastically spike the cost of generic drugs in the past year. As Health and other outlets have reported, other companies have become well known for similar practices. Valeant Pharmaceuticals, for example, bought the rights to two heart drugs Isuprel and Nitropress back in February and then immediately hiked the list prices by 500% and  200% respectively.

But Turing Pharmeceuticals continues to demonstrate one of the most obscene price-spikes ever seen in the industry at a whopping 5,000%. So it’s not surprising that the CEO of the company, Martin Shkreli, has received a lot of backlash in the past few months.

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On Twitter, Shreki refuted criticism by saying “We spend more than 50% of our revenue on R&D. Please get your facts straight before lumping us in with others.”

Fortunately, other companies like Imprimis are trying to make necessary drugs like Daraprim more affordable for the public.

“While we respect Turing’s right to charge patients and insurance companies whatever it believes is appropriate, there may be more cost-effective compounded options for medications, such as Daraprim, for patients, physicians, insurance companies and pharmacy benefit managers to consider,” Imprimis CEO Mark Baum added said in the press release.

Shkreli mentioned last month that he plans to lower the cost of Daraprim. But the new price remains unknown.

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