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Inhalable Ebola Vaccine Works in Monkeys

MONDAY, July 13, 2015 (HealthDay News) — An inhalable Ebola vaccine protected monkeys against the deadly virus, a new study shows.

Research suggests that the linings of the airways may be an important point of entry for the Ebola virus into the body. This was the first test of a inhalable Ebola vaccine, the researchers said.

“A needle-free, inhalable vaccine against Ebola presents certain advantages. Immunization will not require trained medical personnel,” study author Michelle Meyer said in a University of Texas Medical Branch (UTMB) at Galveston news release. Meyer is a postdoctoral fellow in its pathology department.

She and her colleagues found that the inhalable vaccine protected rhesus macaque monkeys against severe illness and death when they were exposed to the Ebola virus.

The findings were published July 13 in the Journal of Clinical Investigation.

“This study demonstrates successful aerosol vaccination against a viral hemorrhagic fever for the first time,” study senior author and virologist Alex Bukreyev, a professor at UTMB, said in the news release.

“A single-dose aerosol vaccine would enable both prevention and containment of Ebola infections, in a natural outbreak setting where health care infrastructure is lacking or during bioterrorism and biological warfare scenarios,” he added.

The researchers will apply for approval to conduct human clinical trials of the inhalable Ebola vaccine.

More information

The U.S. Centers for Disease Control and Prevention has more about Ebola.





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Prenatal Gene Tests Can Sometimes Spot Cancer in Mom-to-Be

By Kathleen Doheny
HealthDay Reporter

MONDAY, July 13, 2015 (HealthDay News) — Abnormal results on noninvasive, prenatal genetic tests don’t always indicate a problem with the fetus. In some cases, these tests may uncover maternal cancers, a new study reports.

“If the test comes back abnormal, the patient should not panic,” said study researcher Dr. Diana Bianchi, executive director of the Mother Infant Research Institute at Tufts Medical Center in Boston. “It doesn’t necessarily mean anything is wrong with the fetus.”

In her study, 10 women had abnormal findings on a noninvasive prenatal test. A more invasive follow-up test found normal results for the fetus, but the test also revealed cancer in the mother.

The findings, Bianchi said, point to the need to do further tests if the noninvasive blood test comes back positive. The chances of this happening are low, she said, but it’s crucial to consider the possibility.

“Cancer is not that common in pregnant women,” Bianchi said. “It [affects] about one in 1,000.”

While the cancer diagnosis is not welcome news either, getting the abnormal test result initially may result in an earlier diagnosis and a better prognosis for a woman with cancer, the authors said.

The study is published in the July 13 online edition of the Journal of the American Medical Association. Funding for the study was provided by Illumina, a company that makes a noninvasive prenatal test (NIPT). Bianchi is a member of an advisory panel for Illumina.

Noninvasive prenatal testing is a screening test that has become widely available in the last four years or so, Bianchi said. It is a screening test that analyzes the mother’s blood, which contains fragments of both placental and maternal DNA. The test looks for certain fetal abnormalities associated with specific chromosomes that may indicate birth defects or a condition, such as Down’s syndrome, according to background information in the study.

NIPT can be done as early as the 10th week of pregnancy and is typically offered to women with high-risk pregnancies, such as older mothers or those with a family history of certain birth defects such as Down’s syndrome, according to the American College of Obstetricians and Gynecologists.

In women with cancer, the blood sample from NIPT will also contain cancer DNA. “If someone has cancer, the tumor itself is shedding DNA in the mother’s blood,” Bianchi said. “The test is picking up excess amounts of DNA from particular chromosomes. It’s kind of an accident in a way that the test is picking up the DNA from the tumor.”

For the study, Bianchi looked at more than 125,000 samples from women who had NIPT between 2012 and 2014. Of that number, more than 3,700 had positive results for one or more abnormalities in five different chromosomes linked with birth defects. Later, 10 of these women were diagnosed with cancer, the study found.

The more fetal abnormalities the test picked up, the greater the likelihood that the pregnant woman had cancer, Bianchi found. Normally, the test may pick up one abnormality, she said.

“But seven of the 10 women had more than one,” which is unusual. “If it’s just a single abnormality, it’s much less likely to be cancer,” she said.

The chance that the abnormal NIPT result is due to cancer is small, said Dr. Roberto Romero, chief of the perinatology research branch at the U.S. National Institute of Child Health and Human Development of the National Institutes of Health. He reviewed the findings and wrote an editorial to accompany the study.

For women, the bottom line is that if the results of the blood test come back abnormal, they should next have a diagnostic test, such as amniocentesis, according to Romero.

“An important message is that the NIPT is not a screening test for cancer during the pregnancy,” he said.

Women should be made aware of the possibility of this result when they undergo the NIPT, Bianchi said. If the test comes back abnormal, they need a follow-up diagnostic test, she agreed.

More information

To learn more about prenatal testing, read this information from the American Congress of Obstetricians and Gynecologists.





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Banning Soccer ‘Headers’ Won’t Solve Concussion Problem: Study

By Alan Mozes
HealthDay Reporter

MONDAY, July 13, 2015 (HealthDay News) — While many experts have called for a ban on “heading” the ball in youth soccer because they believe it is a leading cause of concussions, a new study suggests the body contact that often occurs during such play is to blame for most brain injuries.

So banning headers among high school players would not reduce concussion rates as much as enforcing existing rules on rough play would, the researchers added.

Heading the ball “is very much at the heart of soccer culture,” explained study author R. Dawn Comstock, a faculty member in the department of epidemiology with the Colorado School of Public Health at the University of Colorado in Aurora. “And, yes, we found that heading is the activity in soccer during which most concussions occur among both boys and girls,” she added.

“But if you look closely, it’s not generally the impact of the ball to the head that leads to concussion. The vast majority of the time it’s the athlete-to-athlete contact that happens during [heading] that causes the concussion. One player’s head hitting another player’s head, or a shoulder-to-head [collision]. That’s the problem. Not the ball,” Comstock explained.

“So, yes, if you eliminate heading in soccer you would definitely reduce concussions,” Comstock acknowledged. “But soccer is not actually a full-contact sport. And there are rules of the game that already exist that penalize the kind of dangerous out-of-position contested heading that results in athlete-to-athlete contact.”

So, she suggested, “if you just enforce these rules you would dramatically reduce aggressive body contact, and dramatically lower the concussion rate, without having to change the culture of the sport by eliminating heading itself.”

The findings are published in the July 13 online edition of the journal JAMA Pediatrics.

Soccer’s popularity among U.S. high school students has grown enormously in recent years. Today, almost 800,000 teens play the sport in the United States, compared with the mere 50,000 (exclusively male) students who played back in 1970, according to the report.

An analysis of data collected between 2005 and 2014 showed that today, girls actually face a higher risk for soccer concussions than boys: 4.5 concussions for every 10,000 practice or game exposures, compared with just 2.8 concussions per 10,000 exposures among boys.

Heading is the most concussion-prone activity, accounting for more than 30 percent of all concussions among boys, and more than 25 percent among girls, the investigators reported.

However, 78 percent and 62 percent of heading-related concussions among boys and girls, respectively, were attributed to body-on-body contact between players, rather than head contact with the ball, the study said.

“Based on this evidence, I would say that if soccer officials are going to allow the sport to become increasingly aggressive then, yes, please ban heading,” said Comstock. “But be clear that what’s causing concussions is not the ball. It’s athlete contact.”

But Robert Stern, a professor of neurology, and neurosurgery and anatomy and neurobiology at Boston University School of Medicine, argued that the current study “really misses the point.”

“I’m a soccer fan and a major supporter of youth athletics of all different types,” he said. “And we must keep in mind the incredible benefits of youth sports, including sports that result in a lot of injuries. But I do completely support those who want to eliminate heading in soccer at a young age, because the intense focus we’ve been having on the so-called ‘concussion crisis’ in recent years misses the much bigger issue: What happens to brains when they are exposed to repetitive hits to the head?” Stern said.

“I don’t expect there to be a lot of concussions caused directly by heading a ball,” stressed Stern, who also serves as the clinical core director of the university’s Alzheimer’s disease and CTE Center.

“But I’m talking about all the long-term consequences that come from ‘sub-concussive’ hits, absent any concussive symptoms. The repetitive brain trauma that comes with hitting the ball frequently with the head, causing changes to the white matter integrity of the brain, cognitive [mental] changes, and other alterations to brain functioning,” he explained.

“And I would say that parents who struggle with trying to understand this issue need to ask one very important question: Does it make sense for us to allow for our young kids to participate in an activity that results in repetitive brain trauma?” he said. “Personally, I think children deserve to have adults protect their developing brains.”

More information

There’s more on brain injury and sports at the U.S. Centers for Disease Control and Prevention.





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U.S. FDA Approves New Drug for Schizophrenia, Major Depression

MONDAY, July 13, 2015 (HealthDay News) — A new drug to treat schizophrenia and depression has been approved by the U.S. Food and Drug Administration.

Rexulti (brexpiprazole) tablets can be used to treat adults with schizophrenia. The new drug can also be used as an add-on therapy to antidepressant drugs for adults with major depression.

“Schizophrenia and major depressive disorder can be disabling and can greatly disrupt day-to-day activities,” Dr. Mitchell Mathis, director of the Division of Psychiatry Products in the FDA’s Center for Drug Evaluation and Research, said in an agency news release.

“Medications affect everyone differently so it is important to have a variety of treatment options available for patients with mental illnesses,” he added.

The FDA’s approval of Rexulti for treatment of schizophrenia is based on two six-week clinical trials with more than 1,300 people. People taking the drug had fewer symptoms of schizophrenia than those who took a placebo, the studies found.

Rexulti was also tested as an add-on therapy for major depression. For this treatment, researchers conducted two six-week clinical trials. The trials included more than 1,000 patients whose symptoms were not adequately treated by taking an antidepressant alone. Those who took Rexulti and an antidepressant had fewer symptoms of depression than those who took a placebo and an antidepressant, the FDA said.

Weight gain and a sense of restlessness were the most common side effects reported by patients taking Rexulti. The drug is made by Otsuka Pharmaceutical Company Ltd. in Japan.

Like other schizophrenia drugs, Rexulti has a boxed warning about an increased risk of death associated with unapproved use of the drugs to treat behavioral problems in people with dementia-related psychosis.

The boxed warning also cautions about an increased risk of suicidal thoughts and behavior in children, teens and young adults taking antidepressants. People taking the drug should be monitored for the start or worsening of suicidal thoughts and behavior, the FDA said.

More information

The U.S. National Institute of Mental Health has more about schizophrenia.





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U.S. FDA Approves New Drug for Schizophrenia, Major Depression

MONDAY, July 13, 2015 (HealthDay News) — A new drug to treat schizophrenia and depression has been approved by the U.S. Food and Drug Administration.

Rexulti (brexpiprazole) tablets can be used to treat adults with schizophrenia. The new drug can also be used as an add-on therapy to antidepressant drugs for adults with major depression.

“Schizophrenia and major depressive disorder can be disabling and can greatly disrupt day-to-day activities,” Dr. Mitchell Mathis, director of the Division of Psychiatry Products in the FDA’s Center for Drug Evaluation and Research, said in an agency news release.

“Medications affect everyone differently so it is important to have a variety of treatment options available for patients with mental illnesses,” he added.

The FDA’s approval of Rexulti for treatment of schizophrenia is based on two six-week clinical trials with more than 1,300 people. People taking the drug had fewer symptoms of schizophrenia than those who took a placebo, the studies found.

Rexulti was also tested as an add-on therapy for major depression. For this treatment, researchers conducted two six-week clinical trials. The trials included more than 1,000 patients whose symptoms were not adequately treated by taking an antidepressant alone. Those who took Rexulti and an antidepressant had fewer symptoms of depression than those who took a placebo and an antidepressant, the FDA said.

Weight gain and a sense of restlessness were the most common side effects reported by patients taking Rexulti. The drug is made by Otsuka Pharmaceutical Company Ltd. in Japan.

Like other schizophrenia drugs, Rexulti has a boxed warning about an increased risk of death associated with unapproved use of the drugs to treat behavioral problems in people with dementia-related psychosis.

The boxed warning also cautions about an increased risk of suicidal thoughts and behavior in children, teens and young adults taking antidepressants. People taking the drug should be monitored for the start or worsening of suicidal thoughts and behavior, the FDA said.

More information

The U.S. National Institute of Mental Health has more about schizophrenia.





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J.K. Rowling’s Awesome Response to a Mean Tweet About Serena Williams

We already know author J.K. Rowling is simply great at Twitter. For example, when she tweeted “warn me next time” in response to that time grown-up, real-life Neville Longbottom (actor Matthew Lewis) stripped down for a steamy magazine cover shoot. And how about all the time the Harry Potter author spends interacting personally with her many fans?

But this weekend she may have delivered her best yet with her brief, yet powerful reaction to one man who attempted to body-shame tennis star Serena Williams. She did not mince words, that’s for sure.

 

RELATED: Here’s Why Serena Williams Cherishes Her Friendship With One of Her Biggest Rivals, Caroline Wozniacki

Not only did she celebrate the athlete’s beauty and strength on Twitter, she got to congratulate her in person after the 6-4, 6-4 match.

 

It doesn’t appear that Williams, who now has six Wimbledon wins, 21 Grand Slam titles, was at all bothered by this one guy’s comment on the Internet. Exhibit A: She posted an Instagram of her killer look at the Champions’ Dinner with the caption “Swerve.”

 

Instagram Photo

 

And then there’s also this adorable video of her dancing with the men’s winner Novak Djokovic later that night.

 

Still, even if Williams didn’t need to hear it, we did. It’s lovely to see someone with Rowling’s reach shut down that kind of heartless and totally unnecessary negativity.

RELATED: You’ll Love How Serena Williams Responded to ‘Racist,’ ‘Sexist’ Comments

 

 




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1 in 6 Americans Too Far From Lifesaving Heart Centers

MONDAY, July 13, 2015 (HealthDay News) — Tens of millions of rural, poor and Hispanic Americans do not have timely access to a lifesaving heart procedure, a new study finds.

Researchers analyzed the driving times for 306 million people to reach the closest angioplasty centers across the continental United States.

Angioplasty is used to open blocked heart arteries. A catheter is used to insert a deflated balloon into the artery. The balloon is then inflated to open the artery and restore blood flow to the heart. There are more than 1,700 angioplasty centers in the United States, the researchers said.

The median time to an angioplasty center was 33 minutes, they found. However, the median travel time for more than 16 percent of the population — about 50 million people — was 81 minutes, according to the study.

Results were published July 13 in the journal Health Services Research.

It shouldn’t take longer than 120 minutes from the time a heart attack patient has first contact with medical help to the inflation of the balloon in a blocked heart artery, the American Heart Association and the American College of Cardiology recommend.

Longer travel times to angioplasty centers could lead to worse outcomes for millions of patients, said study senior author Dr. Renee Hsia, a professor of emergency medicine and health policy at the University of California, San Francisco, in a university news release.

“While our results show that the 84 percent of the continental U.S. population live within 60 minutes of a hospital with an angioplasty facility, we have to recognize that the remaining 16 percent do not have timely access to these centers, which should be reflected in pre-hospital treatment protocols to optimize other methods of management,” she said.

Rural residents were more likely to have longer travel times to angioplasty centers. The researchers also found that poor and Hispanic Americans in both cities and rural areas were more likely to have poorer access to angioplasty centers.

Poor and Hispanic patients were three and 2.5 times more likely, respectively, to reach an angioplasty center more than 60 minutes after first contact with medical help.

These findings are especially significant in light of well-documented disparities and outcomes for poor and minority heart attack patients, Hsia said.

In 2000, the median distance to an angioplasty center was 7.9 miles and 79 percent of Americans lived within an hour of a center. That improved to 7.4 miles and 84 percent, respectively, in 2011, the researchers said.

While those figures suggest improved access, many new angioplasty centers have opened in areas with the lowest need — “in competitive markets, often with high private insurance penetration” — and where angioplasty services may already be present, the researchers noted.

More information

The U.S. National Heart, Lung, and Blood Institute has more about coronary angioplasty.





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Climate Change May Already Be Costing American Lives

By Randy Dotinga
HealthDay Reporter

MONDAY, July 13, 2015 (HealthDay News) — New research suggests that U.S. climate change, and the unpredictable temperature swings it can bring, may boost death rates in seniors.

“Temperature variability emerges as a key feature in the potential impacts of climate change. The take-home message: Unusual temperature is bad for people’s health,” said study author Liuhua Shi, a graduate student in the department of environmental health at Harvard’s School of Public Health in Boston.

Scientists have long been debating the health effects of climate change, and the general assumption is that it will make people sicker through more extreme heat, more flooding and more polluted air.

Shi and colleagues launched their study in the New England area to better understand how weather affects death rates. “Many studies have reported associations between short-term temperature changes and increased daily deaths,” Shi said. “However, there is little evidence to date on the long-term effect of temperature.”

The researchers looked at Medicare statistics regarding 2.7 million people over the age of 65 in New England from 2000 to 2008. Of those, Shi said, 30 percent died during the study.

The researchers found death rates rose when the average summer temperature rose significantly, and death rates dropped when the average winter temperature rose significantly.

The researchers believe the increased risk in the summer is due to an increase in the variability of temperatures. According to Shi, “climate change may affect mortality rates by making seasonal weather more unpredictable, creating temperature conditions significantly different to those to which people have become acclimatized.”

On the other hand, warmer winter temperatures caused by climate change could actually reduce deaths, the researchers added.

The study notes that research has suggested it’s more difficult for people to develop exercise endurance when they’re in variable temperatures compared to consistently hot conditions. This, the researchers wrote, could explain why variable temperatures spell trouble.

The study has weaknesses. The researchers don’t know what people died of, and it’s impossible to predict the exact effects of climate change and global warming on the variability of temperatures.

Also, the study only found a possible association between weather and death rates, and not a direct cause-and-effect relationship.

Richard Keller, a professor of medical history and bioethics at University of Wisconsin-Madison, studies climate change’s potential effects on health.

“This is clearly an important study. It is valid and useful within certain limits,” said Keller, who was not involved with the study.

What’s next?

“We would expect that people will respond differently to climate change in different climate zones,” Shi said. “Hence, we plan to do a national study to examine the long-term effects of temperature on mortality in each climate zone.”

Meanwhile, Keller said, “The big mysteries concern our adaptability to a changing climate. What kinds of solutions will humans imagine to adapt to a changing climate, and to whom will these solutions be available?”

The study appears in the July 13 issue of Nature Climate Change.

More information

For more about the health impacts of climate change, try the U.S. National Institute of Environmental Health Sciences.





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Wild Mushrooms Might Be Your Last Meal

By Steven Reinberg
HealthDay Reporter

MONDAY, July 13, 2015 (HealthDay News) — A healthy 52-year-old woman who ate wild mushrooms growing in a Canadian park nearly died from her error.

Within 12 hours, she was in an emergency room with severe abdominal pain, nausea, vomiting and diarrhea. After 36 hours, she was in intensive care and on a list for a liver transplant.

Mistaking toxic mushrooms for edible ones is common and sometimes deadly, researchers warn.

“Even for experienced foragers it can be difficult to tell what is poisonous and what is not,” said Dr. Corey Stein, from the department of medicine at the University of Toronto in Canada. “People who forage need to be aware of the dangers of eating wild mushrooms.”

In the July 13 issue of the CMAJ (Canadian Medical Association Journal), Stein and colleagues tell the tale of this Asian immigrant in Canada. Her husband had experience foraging in his native country. However, they picked mushrooms he mistook for ones they had eaten safely before.

The mushrooms she ate were the toxic Amanita bisporigera species, also called “death cap” mushrooms. Mushrooms belonging to the Amanita species, which has more than 600 types, cause most deaths from mushroom poisoning, the researchers explained. However, other toxic mushrooms exist in North America.

When the patient went to the emergency room, she took the mushrooms with her, which enabled doctors to identify the toxin.

The poison, which has no antidote, attacked her liver. Without the liver transplant, she would have died.

Foraging for mushrooms is becoming increasingly popular, the study authors said. While poisonings are likely underestimated, the researchers said about 6,000 exposures to toxic mushrooms are reported each year in the United States. Most are linked with mild symptoms.

Michael Beug is chairman of the toxicology committee at the North American Mycological Association, a non-profit organization concerned with the study of fungi. The problem is lack of knowledge of toxic species, he said.

“If we can get people interested in foraging wild mushrooms to join a club and learn how to distinguish the edible species, they can forage wild mushrooms with a high degree of safety,” Beug said. His organization has 80 affiliated clubs and more than 1,500 members.

Poisoning from toxic mushrooms has three phases, Stein explained: Gastrointestinal symptoms include pain, nausea, vomiting and diarrhea, which start within six to 24 hours after ingestion. This is followed by a false recovery period when the patient appears to improve. In the final phase, which happens 48 hours after ingestion, the liver begins to fail, leading to multi-organ failure and possibly death.

Another medical expert thinks the risks of collecting and eating wild mushrooms are so great that people should avoid doing it entirely.

“Foraging for mushrooms is a dangerous practice, with even trained persons unable to always identify safe mushrooms to eat,” said Dr. Robert Glatter, an emergency physician at Lenox Hill Hospital in New York City.

“The risk of developing liver failure, potentially requiring a liver transplant — and even the possibility of death — should serve as a deterrent to avoid foraging for wild mushrooms,” Glatter said.

More information

For more on mushroom poisoning, visit the North American Mycological Association.





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Why Being An Adventurous Eater Could Help You Lose Weight

Photo: Getty Images

Photo: Getty Images

Do you see kimchi listed as a side dish on the menu, and think, Yum! Would you be up for ordering beef tongue, rabbit, or polenta? Well, you may weigh less and even be healthier than your not-as-adventurous counterparts, a new study out of the Cornell Food and Brand Lab found.

Researchers surveyed over 500 women about their eating habits, lifestyle choices, and BMIs. They found that those who had tried the most foods (including those mentioned above) also had lower BMIs, exercised more, and were more mindful of the health factor of their food compared to those who didn’t tend to eat outside the box.

RELATED: No More Nuggets! New Ways to Deal With Picky Eaters

So why might being an adventurous eater help you stay slim? Perhaps it’s because trying new foods may open you up to tasty vegetables and lean protein sources you love, so eating well becomes easier. Plus, a diet that’s personalized to your likes and dislikes makes you feel like you’re choosing a healthy lifestyle, not stuck in some sort of confining plan that limits you to just a handful of foods.

Co-author Brian Wansink, PhD, author of Slim by Design: Mindless Eating Solutions for Everyday Life confirms in a press release: “These findings are important to dieters because they show that promoting adventurous eating may provide a way for people—especially women—to lose or maintain weight without feeling restricted by a strict diet.”

The takeaway? “Instead of sticking with the same boring salad, start by adding something new. It could kickstart a more novel, fun and healthy life of food adventure,” Wansink advises. Pass the polenta!

RELATED: Picky Eaters? Genes to Blame for Finicky-About-Food Kids

 




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