barre

DNA Tests May Spot Brain Infections

FRIDAY, June 24, 2016 (HealthDay News) — Genetic testing may help diagnose or rule out brain infections, researchers report.

They said their pilot study showed that using computers to rapidly analyze large amounts of genetic and biological information from brain tissue samples could offer a cost-effective addition to pathology lab testing.

The research team from Johns Hopkins University in Baltimore noted that more than 50 percent of inflammatory disorders and infections of the brain go undiagnosed, resulting in patients receiving treatments for individual symptoms that can do more harm than good.

The study included 10 patients, aged 16 to 68, with signs of brain infection, including fever, weakness in limbs, partial paralysis, numbness, headache or seizures. The researchers took a sample from an area of inflamed, damaged brain tissue and sequenced the DNA in the tissue.

They looked for evidence of bacteria, viruses and other pathogens that could cause infection.

“By incorporating modern genetic sequencing techniques into pathology diagnostics, we were able to investigate the potential presence of infection in 10 subjects and found appropriate explanations of clinical problems in eight out of 10 patient cases examined in this study,” said study author Dr. Carlos Pardo-Villamizar, an associate professor of neurology at Hopkins.

“We hope to develop this technique further as a way to bring the diagnosis rate of inflammatory brain disorders and infections closer to 100 percent so we can treat patients more effectively,” he said in a university news release.

The study was published online recently in the journal Neurology: Neuroimmunology & Neuroinflammation.

More information

The Merck Manual has more on brain infections.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/294PlOT

Diabetes Ups Risk of Heart Attack Death

FRIDAY, June 24, 2016 (HealthDay News) — People with diabetes are much more likely to die after a heart attack than people without the blood sugar condition, a new study finds.

Researchers included 700,000 people in the study. All of them were hospitalized with a heart attack between January 2003 and June 2013. About 121,000 had diabetes.

Compared to people who didn’t have diabetes, those with the disease were 56 percent more likely to die if they had a heart attack caused by a completely blocked coronary artery. If their heart attack was the result of a partially blocked coronary artery, people with diabetes were 39 percent more likely to die, the study found.

“These results provide robust evidence that diabetes is a significant long-term population burden among patients who have had a heart attack,” said lead researcher Dr. Chris Gale, a consultant cardiologist and associate professor in the School of Medicine at the University of Leeds in the United Kingdom.

“Although these days people are more likely than ever to survive a heart attack, we need to place greater focus on the long-term effects of diabetes in heart attack survivors,” he added in a university news release.

An important step is to strengthen the partnership between primary care doctors, doctors who treat heart problems (cardiologists), and doctors who treat diabetes (endocrinologists), Gale said. He added that doctors need to make sure that high-risk patients are getting established medications as effectively as possible.

This study couldn’t show a cause-and-effect relationship. So, researchers now want to figure out exactly why people with diabetes have a higher risk of death after a heart attack.

“We knew that following a heart attack, you are less likely to survive if you also have diabetes. However, we did not know if this observation was due to having diabetes or having other conditions which are commonly seen in people with diabetes,” Dr. Mike Knapton said. He’s an associate medical director at the British Heart Foundation, which funded the study.

The findings highlight the need to find better ways to prevent heart disease in people with diabetes, he said. The study also shows the need to develop new treatments to improve survival after a heart attack for folks with diabetes, Knapton added.

The study was published recently in the Journal of Epidemiology and Community Health.

More information

The U.S. National Heart, Lung, and Blood Institute has more on heart attack.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/294POQM

Five New Genes Linked to Colon Cancer

FRIDAY, June 24, 2016 (HealthDay News) — Scientists have identified five new gene mutations that may be tied to colon cancer.

The findings are from an analysis of genes from more than 1,000 people with colon cancer. The links between these five gene mutations were very rare, so further research is needed to confirm if they’re actually associated with colon cancer.

The study authors also concluded that all the major genes that significantly increase the risk of colon cancer have been identified.

“Our study is the largest ever conducted of the genetics of bowel [colon] cancer, and sets out a detailed map of the disease that could lead us to new ways of treating or preventing it,” study leader Richard Houlston, a professor of molecular and population genetics at the Institute of Cancer Research in London, said in an institute news release.

“The research closes one chapter in the study of bowel cancer, by concluding that all the major risk genes have now been found. But, it opens another by underlining the importance of tracking down the many missing genetic variations which each have a very small effect alone, but together make the biggest impact on inherited risk,” he explained.

Every cancer gene that’s been found, as well as those genetic variants that may continue to be found, gives researchers new insight into the underlying biology of colon cancer. These discoveries also help to assess people for their risk of colon cancer, Houlston said.

“This study represents an important contribution to our understanding of the genetics of bowel cancer. It provides a marker of the dramatic progress we have made so far in decoding the inherited risk of the disease, and gives us confidence that the most important risk genes have now been found,” Paul Workman, chief executive of the Institute of Cancer Research, said.

The study was published June 22 in the journal Nature Communications.

More information

The U.S. National Cancer Institute has more on colon cancer.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/294PBNF

Smoking May Hinder Common Breast Cancer Treatment

By Steven Reinberg
HealthDay Reporter

FRIDAY, June 24, 2016 (HealthDay News) — Smoking may blunt the effectiveness of a certain kind of breast cancer treatment, new research suggests.

Among breast cancer patients taking a class of drugs called aromatase inhibitors, smokers had a three times greater risk of their cancer returning than nonsmokers, the investigators found. However, the study could not prove a cause-and-effect link.

Smoking had little or no effect on the benefit of other drugs, such as chemotherapy or tamoxifen, or radiation treatment, the study authors added.

“These findings need confirmation. If confirmed, smoking status should be taken into consideration when selecting the type of [breast cancer] therapy,” said lead researcher Helena Jernstrom. She is an associate professor of experimental oncology at Lund University Cancer Center in Sweden.

Common aromatase inhibitors include Arimidex (anastrozole), Aromasin (exemestane) and Femara (letrozole).

These drugs stop production of the hormone estrogen in postmenopausal women. This reduces the estrogen available to stimulate growth of hormone receptor-positive breast cancer cells.

Hormone receptor-positive breast cancer is the most common type of breast cancer, accounting for about two of every three cases. If caught and treated early, 100 percent of patients survive five years or more, according to the American Cancer Society.

It’s not clear why smoking makes aromatase inhibitors less effective, Jernstrom said. Perhaps something in cigarettes makes breast cancer cells resistant to these drugs, she suggested.

In light of these findings, aromatase inhibitors may not be the best choice for women with hormone receptor-positive breast cancer who smoke, since alternative treatments are available that aren’t affected by smoking, Jernstrom said.

Of course, “it is always a good idea to quit smoking,” Jernstrom said. Breast cancer patients who smoke should seek help to quit and doctors should encourage it, she added.

For the study, investigators followed 1,065 women diagnosed with breast cancer between 2002 and 2012. One in five smoked prior to breast cancer surgery.

The researchers found that women 50 or older who were treated with aromatase inhibitors fared considerably worse during the follow-up period if they smoked than if they didn’t.

Only a small percentage of smokers quit during treatment, Jernstrom said. So it isn’t known whether giving up smoking while taking aromatase inhibitors increases the drug’s effectiveness.

The smokers were also more likely to die from their cancer or other illnesses during the roughly five-year follow-up period, the findings showed.

Dr. Stephanie Bernik, another cancer specialist, said smoking increases the risk of many cancers for decades.

Now evidence exists that smoking could shorten the lives of patients with breast cancer taking aromatase inhibitors, she said. Exactly how this happens needs to be made clear, suggested Bernik. She is chief of surgical oncology at Lenox Hill Hospital in New York City.

“What we do know is that more than ever, patients who smoke, even if just socially, need to make an effort to try to kick the habit in order to optimize their chance for survival,” she said.

The study by Jernstrom and colleagues was recently published online in the British Journal of Cancer.

More information

For more on breast cancer, visit the American Cancer Society.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/294PcdX

Flint’s Lead-Contamination Crisis ‘Entirely Preventable’

FRIDAY, June 24, 2016 (HealthDay News) — Analysis of blood samples from young children of Flint, Mich., shows they had much more lead in their blood when the city used local drinking water in an effort to cut costs, a new U.S. government study reveals.

A series of blood samples showed kids younger than 6 were nearly 50 percent more likely to have elevated blood lead levels when the city used the Flint River for drinking water instead of the Detroit water system, researchers from the U.S. Centers for Disease Control and Prevention concluded.

The percentage of kids with high lead content returned to previous levels once the city switched back to the Detroit system. The reason for the lead contamination? Inappropriate corrosion control measures, investigators said.

“This crisis was entirely preventable, and a startling reminder of the critical need to eliminate all sources of lead from our children’s environment,” Patrick Breysse, director of CDC’s National Center for Environmental Health, said in an agency news release.

Even low levels of lead in children’s blood can affect intelligence, ability to pay attention and academic achievement, the agency noted.

The blood lead level of concern is 5 or more micrograms of lead per deciliter of blood. During the period that the Flint River water was used (April 25, 2014 to Oct. 15, 2015), lead levels in local tap water increased over time, as did lead content in children’s blood, the CDC said.

The CDC has advised that all children under age 6 in Flint have their blood tested for lead by a health care provider.

According to Dr. Nicole Lurie, U.S. Department of Health and Human Services’ Assistant Secretary for Preparedness and Response, “Parents and teachers can do a lot to help children grow up healthy and strong, even if they were exposed to lead.”

She said the city’s children are getting developmental assessments and needed services. “We have also expanded Medicaid and strongly urge parents to enroll their children and schedule appointments for them to be seen by a health provider, who can follow their health as they grow and develop,” Lurie said.

Taking advantage of healthy-foods programs and enrolling kids in programs that stimulate their brains such as Head Start are also important, she added.

The Flint crisis has raised concerns about the potential for lead contamination nationwide. Public health experts advise blood-lead testing for children living at or below the poverty level and kids enrolled in Medicaid, the government funded insurance program for the poor. The CDC generally recommends testing at age 1 or 2 years.

In Flint, residents have been advised to use filtered water for drinking, brushing their teeth and cooking.

“It’s very important that Flint residents use lead-certified water filters, which are carefully installed on their faucets,” said Dr. Robert Glatter, emergency physician at Lenox Hill Hospital in New York City.

“It should be pointed out that regular household tap water can be used for showering and bathing since lead is not absorbed through the skin. But it’s still so important that parents guard against young children drinking water from the bath,” he explained.

“Often there are no obvious symptoms early on after lead exposure,” Glatter said, noting it can take years to show up as behavioral issues, learning disabilities and poor school performance. “Some children may also develop chronic abdominal pain and constipation,” he added.

CDC officials said the study can’t prove that the Flint River water directly caused the blood lead elevation. They cited limitations, such as not knowing about lead paint exposure in the children’s homes or whether greater use of bottled water contributed to the decline in lead levels.

Still, this crisis shows “we must continue to screen all children who are at risk for lead exposure — even in the absence of obvious symptoms,” Glatter said.

More information

The U.S. National Institute of Environmental Health Sciences has more about lead poisoning.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/294PkKQ

Many Could Face Steep Rise in Obamacare Premiums for 2017

By Karen Pallarito
HealthDay Reporter

FRIDAY, June 24, 2016 (HealthDay News) — Many buyers of health insurance under the Affordable Care Act need to brace themselves for sharply higher premiums in 2017, analysts and insurance brokers say.

The rate hikes will mainly affect the millions who pay all of the cost of health insurance out of their own pockets — or a sizable chunk of it, they explained.

Buyers with modest incomes, $29,700 to $35,640 for an individual, may qualify for federal subsidies to help lower their monthly health plan premiums if they enroll through HealthCare.gov or their state insurance marketplace. But they don’t get as much financial help as low-income earners, and may feel the pinch of higher rates.

Consumers earning upwards of $47,520 for an individual will certainly be affected. This group of buyers makes too much money to receive federal subsidies. They can shop for health insurance either on or off the marketplaces established as part of the Affordable Care Act (ACA), but they’ll pay the entire premium themselves, the experts said.

One group expected to weather the rate hikes? Low-income Americans who qualify for federal tax credits toward all or most of their health plan premiums.

“When premiums come in higher, low-income people are insulated from those increases because the tax credits wind up being larger,” explained Bradley Herring, an associate professor of health economics at Johns Hopkins University in Baltimore.

“But if you’re not low-income then, no, you actually will face those high premium increases,” he added.

Open enrollment for health insurance coverage through HealthCare.gov for 2017 begins Nov. 1, 2016.

Health insurers have already begun seeking regulatory approval for proposed rate changes, effective Jan. 1, 2017. Initial rate filings vary widely by market, by insurer and by health plan, with some rate hikes in the high double digits.

Blue Cross Blue Shield of Texas has proposed boosting rates by nearly 60 percent, on average, for three of its ACA plans, affecting some 603,000 customers.

In Colorado, Golden Rule Insurance Co., Colorado Choice and Rocky Mountain HMO have submitted rate requests for 2017, ranging from 35 percent to 41 percent higher, on average, according to the state insurance department. At the low end, Denver Health Medical Plan is seeking an average increase of just 0.08 percent.

Under the Affordable Care Act, often called Obamacare, people have a choice of four levels of coverage: bronze, silver, gold and platinum. The second lowest-cost silver plan in a market serves as the benchmark for determining the amount of financial help that consumers may be eligible to receive toward their monthly health plan premiums. Subsidies are provided in the form of federal tax credits.

A recent Kaiser Family Foundation analysis of proposed rates in 14 major cities, including the District of Columbia, found that premiums for those cheaper silver plans could jump 10 percent, on average, versus 5 percent in 2016.

Insurance brokers say the 2017 rate requests largely reflect higher-than-anticipated costs partly due to sicker-than-expected enrollees and the sunset of programs designed to ease insurers’ financial risk in the early years of the Obamacare marketplaces.

Even if an insurer priced its health plans perfectly in 2016, its 2017 rates would reflect anticipated increases in health care costs and the loss of federal payments to insurers with extremely high medical claims, said Karen Bender, a health actuary based in Little Suamico, Wisc.

“That almost gets you into the double digits right there,” she noted.

However, whether state and federal regulators will allow the higher proposed rates to take effect remains to be seen, and those decisions may vary from one market to the next, experts said.

If insurers don’t get the rates they feel they need, either more health plans could drop out of the individual market or they could intensify pressure on doctors and hospitals to accept lower rates, said Bender. That could lead to even more narrow networks if providers don’t agree to those rates, she suggested. Bender serves on the health steering committee of the Conference of Consulting Actuaries.

Consumers are advised to consider all of their expenses and health care needs when selecting a health plan. Premium is just one factor, experts say.

But premiums are important because people have to be able to afford coverage, said Mike Cook, an Alexandria, Va.-based insurance broker.

“If you can’t afford [the premium], then the minute you miss [paying] it, the insurance company will drop you,” he said.

Last year, he said, several of his clients opted to forgo Obamacare coverage altogether because of the expense. Instead, they bought short-term health insurance policies and paid the federal tax penalty for failing to maintain “minimal essential coverage” under the law.

More information

Visit HealthCare.gov to look up premium rate filings in your state.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/29416F8

Opioid Update: Painkiller Misuse in U.S. Doubled in Decade

FRIDAY, June 24, 2016 (HealthDay News) — More bad news from the U.S. drug wars: Misuse of prescription opioid painkillers by American adults more than doubled from the early 2000s to 2013, a new government study says.

Rates of addiction to powerful painkillers such as OxyContin and Vicodin also swelled during that time, according to the U.S. National Institute on Alcohol Abuse and Alcoholism (NIAAA).

“The increasing misuse of prescription opioid pain relievers poses a myriad of serious public health consequences,” said Dr. Nora Volkow, director of the U.S. National Institute on Drug Abuse, which contributed funding for the study. These consequences range from addiction and overdose deaths to use of heroin, an illicit opioid, she said.

Survey results indicated more than 4 percent of adults reported nonmedical use of addictive opioids in 2012-2013. This means they took the drug without a prescription or more of the drug than prescribed or for longer periods or more often. Ten years earlier, less than 2 percent of adults reported such risky behavior.

Moreover, the proportion of adults who reported nonmedical use of opioids at some point in their lives rose from 4.7 percent to more than 11 percent during the study period.

And 2.1 million Americans met the criteria for prescription opioid use disorder, or opioid addiction, in 2012-2013.

The consequence are wide-ranging, Volkow pointed out. “These include increases in opioid use disorders and related fatalities from overdoses, as well as the rising incidence of newborns who experience neonatal abstinence syndrome,” she said in a government news release.

In addition, Volkow said prescription opioid misuse can progress to intravenous heroin use. This in turn raises the risk for HIV, hepatitis C and other infections among people sharing needles, she explained.

According to the report, rates of prescription opioid misuse were highest among: men; people with annual incomes less than $70,000; those previously married; and people with a high school education or less.

Misuse was also higher among whites and Native Americans and those living in the Midwest and West, the study found.

NIAAA director George Koob said, “Given the dramatic increase in nonmedical use of prescription opioids, it is important that clinicians and patients also recognize the potent interaction of opioids with alcohol and other sedative-hypnotic drugs — an interaction that can be lethal.”

People who’ve had an alcohol use disorder are nearly twice as likely to also develop an opioid addiction, government data shows.

Treatment for misuse and abuse of prescription painkillers lags far behind the need, the study suggests.

Only about 5 percent of adults who misused prescription opioids in the past year and 17 percent of those with prescription opioid addiction ever receive treatment, researchers found. Recommended treatment includes medication and behavioral counseling.

The study was published online June 22 in the Journal of Clinical Psychiatry.

More information

The U.S. National Institute on Drug Abuse has more about opioids.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/2940RtC

Diabetes Plus Kidney Problems May Raise Heart Risks

FRIDAY, June 24, 2016 (HealthDay News) — For black Americans with diabetes, poor kidney function appears to boost their risk of dying from heart disease, a new report suggests.

Both kidney disease and diabetes are very common among black people in the United States, the study authors noted.

For the study, researchers reviewed data from more than 3,200 black people in Mississippi who were enrolled in a heart study from 2000 to 2004. The participants were followed for a median of seven years.

The investigators found that the risk of death from heart disease was more than 2 percent higher per year among those with diabetes. The risk of death from heart disease was 7 percent higher in people with kidney disease. But, people with both diabetes and kidney disease fared the worst. Their risk of dying from heart disease was 15 percent higher, the study found.

The study couldn’t prove a cause-and-effect relationship. But the results suggested that having both diabetes and kidney disease was linked to more than a three times increased risk of heart disease and a six times higher risk of stroke.

“African Americans in low-income counties in Mississippi have higher rates of adverse cardiovascular outcomes and mortality than any other subpopulation in the United States (including other African American subpopulations), rates that are comparable to those in some of the most underprivileged parts of the globe,” said study co-leader Dr. Maryam Afkarian, of the University of Washington in Seattle.

Afkarian noted that the researchers wanted to know how much diabetes and kidney disease might contribute to heart disease, stroke and death from heart disease in this group of black people from low-income areas in Mississippi.

“This is an important question because in order to reduce the excess burden of cardiovascular disease and death, it is important to identify the factors that contribute to them,” Afkarian explained in a news release from the American Society of Nephrology.

The study was scheduled for publication in an upcoming issue of the Clinical Journal of the American Society of Nephrology.

More information

The U.S. Office of Minority Health has more about blacks and heart disease.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/28QeEr1

Drug Monitoring Programs Do Curb Overdose Deaths: Study

THURSDAY, June 23, 2016 (HealthDay News) — Drug monitoring programs appear to help reduce deaths from prescription painkillers called opioids, a new study finds.

In an effort to curb overdose deaths from powerful painkillers such as OxyContin and Vicodin, all states except Missouri have implemented prescription-drug monitoring programs to track high-risk patients and prescription providers. But there have been conflicting findings about the effectiveness of these programs.

For instance, a study published June 23 in the New England Journal of Medicine found no change in opioid use or overdoses among disabled workers on Medicare between 2006 and 2012, despite tighter regulations.

But the current study — based on data from 1999 to 2013 — found that monitoring programs were associated with the prevention of about one opioid painkiller overdose death every two hours nationwide.

“Today, opioid overdose deaths are more common than deaths from car crashes. Our study provides support that prescription-drug monitoring programs are part of what needs to be a comprehensive approach to the prescription opioid epidemic,” said lead author Dr. Stephen Patrick, an assistant professor of pediatrics and health policy at Vanderbilt University, in Nashville, Tenn.

The largest reductions in opioid overdose deaths were in states with the most thorough monitoring programs, researchers found. These tracked a greater number of substances with abuse potential and updated their data at least weekly.

Although the study can’t prove causality, states with the most thorough programs had 1.6 fewer opioid overdose deaths per 100,000 people than states without such programs, according to the study. The findings were published June 22 in the journal Health Affairs.

Between 1999 and 2014, more than 165,000 people died nationwide from prescription opioid overdoses, according to the U.S. Centers for Disease Control and Prevention. The drugs are frequently misused because they produce euphoria as well as pain relief.

“Congress is currently considering legislation to bolster the U.S. public health response to the opioid epidemic. Our findings suggest that investments in upgraded prescription-drug monitoring programs will pay dividends in lives saved,” Patrick said in a Vanderbilt news release.

More information

The U.S. National Institute on Drug Abuse has more about opioids.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/28TwLx2

Keep Safe When Temperatures Soar

THURSDAY, June 23, 2016 (HealthDay News) — With high temperatures moving across the United States this weekend, one emergency medicine specialist warns of the health dangers posed by the heat — and offers advice on how to keep cool as the mercury rises.

“Although preventable, many heat-related illnesses, including deaths, occur annually. Older adults, infants and children, and people with chronic medical conditions are particularly susceptible. However, even young and healthy individuals can succumb to the heat if one does not take appropriate precautions,” said Dr. Barry Rosenthal, chair of the department of emergency medicine at Winthrop-University Hospital, in Mineola, N.Y.

He outlined how to reduce the risk of heat-related illnesses during hot weather. One of the best ways is to be in an air-conditioned building. If your home doesn’t have air conditioning, go to a cooling center or an air-conditioned public place such as a library or shopping mall.

Wear loose, lightweight and light-colored clothing, wear a hat or use an umbrella, and apply sunscreen to any exposed skin. It’s also important to drink plenty of water in order to stay hydrated. Avoid alcoholic, caffeinated and sugary beverages, Rosenthal advised.

Ask your doctor or pharmacist if any medications you’re taking increase your risk of heat-related illness. For example, diuretics (water pills) can pose a risk during hot weather. If you’re taking a medication that ups the risk of heat-related problems, ask your doctor if there are additional steps you need to take to reduce the risk.

If possible, limit strenuous outdoor activity and exercise to early morning or evening, when temperatures are lower. Monitor local news and weather channels or contact your local public health department during extreme heat for health and safety updates.

Check on people who are at increased risk for heat-related illnesses, such as elderly loved ones and neighbors.

“At first signs of heat illness — dizziness, nausea, headaches, muscle cramps — move to a cooler place, rest a few minutes, then slowly drink a cool beverage. Seek medical attention immediately if conditions do not improve,” Rosenthal said.

More information

The U.S. Centers for Disease Control and Prevention has more about extreme heat and health.





from Health News / Tips & Trends / Celebrity Health http://ift.tt/28TwQAK